top of page

Selected publications


Cell cycle exit and stem cell differentiation are coupled through regulation of mitochondrial activity in the Drosophila testis.

Diego Sainz de la Maza, Silvana Hof-Michel, Lee Phillimore, Christian Bökel, Marc Amoyel

Cell Reports 2022 May 10;39(6):110774

A kinase translocation reporter reveals real-time dynamics of ERK activity in Drosophila

Alice C. Yuen, Anadika R. Prasad, Vilaiwan M. Fernandes, Marc Amoyel

Biology Open 2022 11(5): bio059364

mRNA Translation Is Dynamically Regulated to Instruct Stem Cell Fate

Ruoxu Wang, Marc Amoyel

Front. Mol. Biosci. 2022 March 31; 9:863885.

An improved Erk biosensor reveals oscillatory Erk dynamics driven by mitotic erasure during early development

Scott G. Wilcockson, Luca Guglielmi, Pablo Araguas Rodriguez, Marc Amoyel, Caroline S. Hill.

bioRxiv 2022

ERK-KTR 2.jpg


An Immobilization Technique for Long-Term Time-Lapse Imaging of Explanted Drosophila Tissues.

Matthew P. Bostock, Anadika R. Prasad, Rita Chaouni, Alice C. Yuen, Rita Sousa-Nunes, Marc Amoyel and Vilaiwan M. Fernandes

Front. Cell Dev. Biol. 2020 October 06;8:1074

Bostock et al 2020


Somatic stem cell differentiation is regulated by PI3K/Tor signaling in response to local cues.
Amoyel M*, Hillion KH, Margolis SR, Bach EA*. *Corresponding authors
Development. 2016 Nov 1;143(21):3914-3925.

Socs36E Controls Niche Competition by Repressing MAPK Signaling in the Drosophila Testis.
Amoyel M, Anderson J, Suisse A, Glasner J, Bach EA.
PLoS Genet. 2016 Jan 25;12(1):e1005815

PLoS gen 2016 fig.jpg


An ancient defense system eliminates unfit cells from developing tissues during cell competition.
Meyer SN*, Amoyel M*, Bergantiños C*, de la Cova C, Schertel C, Basler K, Johnston LA. *Co-first authors
Science. 2014 Dec 5;346(6214):1258236

Neutral competition of stem cells is skewed by proliferative changes downstream of Hh and Hpo.
Amoyel M*, Simons BD, Bach EA*. *Corresponding authors
EMBO J. 2014 Oct 16;33(20):2295-313

JAK/STAT pathway dysregulation in tumors: a Drosophila perspective.
Amoyel M, Anderson AM, Bach EA.
Semin Cell Dev Biol. 2014 Apr;28:96-103

Cell competition: how to eliminate your neighbours.
Amoyel M*, Bach EA*. *Corresponding authors
Development. 2014 Mar;141(5):988-1000

Embo 2014 fig.jpg


Functions of the Drosophila JAK-STAT pathway: Lessons from stem cells.
Amoyel M, Bach EA.
JAKSTAT. 2012 Jul 1;1(3):176-83

JAKSTAT 2012 fig.jpg


Proliferative stem cells maintain quiescence of their niche by secreting the Activin inhibitor Follistatin.

Salvador C. Herrera, Diego Sainz de la Maza, Lydia Grmai, Shally Margolis, Rebecca Plessel, Michael Burel, Michael O’Connor, Marc Amoyel, Erika A. Bach

Dev Cell. 2021 Aug 2: S1534-5807 (21)00593-1

Germ cells commit somatic stem cells to differentiation following priming by PI3K/Tor activity in the Drosophila testis.

Alice C. Yuen, Kenzo-Hugo Hillion, Ruoxu Wang, Marc Amoyel

PLoS Genet. 2021 Dec 13;17(12): e1009609.

Preprint version here:

Stem cells commit to differentiation following multiple induction events in the Drosophila testis.

Alice C Yuen, Kenzo-Hugo Hillion, Marc Amoyel

bioRxiv 2021

Cell cycle exit and stem cell differentiation are coupled through regulation of mitochondrial activity in the Drosophila testis.

Diego Sainz de la Maza, Silvana Hof-Michel, Lee Phillimore, Christian Bökel, Marc Amoyel

bioRxiv 2021

Dev cell graphical abstract.jpg


Regulation of NOTCH signaling by RAB7 and RAB8 requires carboxyl methylation by ICMT.

Court H, Ahearn IM, Amoyel M, Bach EA, Philips MR.

J Cell Biol. 2017 Dec 4;216(12):4165-4182

Neutral Competition for Drosophila Follicle and Cyst Stem Cell Niches Requires Vesicle Trafficking Genes.

Cook MS, Cazin C, Amoyel M, Yamamoto S, Bach E, Nystul T.

Genetics. 2017 Jul;206(3):1417-1428.

cook fig.png


Gut stem cells, a story of snails, flies and mice.

Amoyel M.

EMBO J. 2015 May 12;34(10):1287-9.

MT-Nanotubes: Lifelines for Stem Cells.

Amoyel M, Bach EA.

Cell Stem Cell. 2015 Aug 6;17(2):133-4.

Embo 2015 fig.jpg


Hedgehog is required for CySC self-renewal but does not contribute to the GSC niche in the Drosophila testis. Amoyel M, Sanny J, Burel M, Bach EA. Development. 2013 Jan 1;140(1):56-65

Isoprenylcysteine carboxylmethyltransferase deficiency exacerbates KRAS-driven pancreatic neoplasia via Notch suppression.

Court H, Amoyel M, Hackman M, Lee KE, Xu R, Miller G, Bar-Sagi D, Bach EA, Bergö MO, Philips MR.
J Clin Invest. 2013 Nov;123(11):4681-94.

JAK/STAT signaling is required for hinge growth and patterning in the Drosophila wing disc.
Ayala-Camargo A, Anderson AM, Amoyel M, Rodrigues AB, Flaherty MS, Bach EA.
Dev Biol. 2013 Oct 15;382(2):413-26

Dev 2013 fig.jpg
bottom of page