Cell cycle progression and competitive behaviour

Stem cells that proliferate faster out-compete their neighbours and colonise the niche. How the cell cycle rate affects this competitive ability is not understood.
Using live imaging, we are studying what happens to individual stem cells before, during and after cell division, and using that information to understand how the cell cycle length affects competitive behaviour. We are using genetics to clonally accelerate or disrupt cell cycle progression in single stem cells and observe how their dynamics are affected.

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©2016 Amoyel lab

Visualising cell cycle progression

The cell cycle phases are labelled by a combination of red and green fluorescent proteins, such that each phase is marked by a particular combination of colours. We can use this to track cell cycle in vivo.